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Glycoengineering of CHO Cells to Improve Product Quality
Chinese hamster ovary (CHO) cells represent the predominant platform in biopharmaceutical industry for the production of recombinant biotherapeutic proteins, especially glycoproteins. These glycoproteins include oligosaccharide or glycan attachments that represent one of the principal components dictating product quality.(1)
A Review on the Current Methods of Chinese Hamster Ovary (CHO) Cells …
The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of the therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein.(2)
Glycoengineering of CHO Cells to Improve Product Quality
On the other hand, many therapeutic antibodies produced in CHO cells only have α2,3-linkage sialic acid on N-glycans due to the absence of α2,6-sialyltransferase [37].(3)
CHO Cells – The Top Expression System of Best Selling Biologic Drugs
According to Huggett, Hodgson and Lähteenmäki (2011) the top five selling biologic drugs in 2010 were Enbrel, Humira, Remicade, Avastin and Rituxin. Of these top sellers, four out of the five are manufactured using CHO cells, all with annual revenues over six billion. Psoriasis, ulcerative Myeloma colitis, ankylosing spondylitis, Crohn’s …(4)
CHO Cell Engineering for Improved Process Performance and Product Quality
Chinese Hamster Ovary (CHO) cells are widely used for the large-scale production of recombinant biopharmaceuticals. However, attempts to express IGF-1 (a mutated human Insulin-like growth factor 1 …(5)
PDF Product Quality Review(s) – Food and Drug Administration
PRODUCT QUALITY REVIEW(S) Page 1 of 8 Department of Health and Human Services Food and Drug Administration … The PF-05280014 drug substance is produced in genetically engineered CHO cells. Trastuzumab-qyyp drug product, TRAZIMERA, is manufactured to the same concentration and presentation as U.S.-licensed Herceptin at 420 mg/vial; however …(6)
CHO Cell Engineering for Improved Process Performance and Product Quality
Enhancing cell-specific productivity can improve final product yields, and modulating endogenous proteins involved in post-translational modifications can lead to tailored product quality. In the following chapters, we have summarized the most relevant cell line engineering techniques currently applied for CHO cell engineering and provide an …(7)
Recent advances in CHO cell line development for … – ScienceDirect
Dec 1, 2020The CHO expression platform for pharmaceutical recombinant protein expression. Mammalian expression-based systems involve various cell lines of different origins, from hamster (CHO, BHK), human (HEK293, HT-1080, PER.C6, CAP, HKB-11, Huh-7) and mouse (NS0, Sp2/0). However, 70% of biologics, and almost all mAbs, are produced in Chinese hamster …(8)
Advances in recombinant antibody manufacturing – PMC
Since the first use of Chinese hamster ovary (CHO) cells for recombinant protein expression, production processes have steadily improved through numerous advances. … In this review, the CHO production system is compared to alternative systems by means of production capacity and product quality. … analyzing product quality early in …(9)
CHO Cell Line Investigation for CMC Readiness – BioProcess …
Jun 10, 2020Development of a safe and high-quality Chinese hamster ovary (CHO) cell line is of paramount importance for the chemistry, manufacturing, and controls (CMC) portion of studies that support investigational new drug (IND) applications ( 1, 2 ). Desirable attributes of a CHO cell line include its ability to. produce high titers of biotherapeutic …(10)
CHO Cell Line: From Reliable Workhorse to State-of-the-art Protein …
Mar 9, 2021Over time, enhances increased productivity with the variant becoming better adapted to media and making that protein. The continuous evolution of using a specific CHO cell line then adapting it to a specific media and creating an environmental platform for cell growth has enabled the move from .1-.2 g/L in the 1990’s to 5-10 g/L currently.(11)
HEK cells vs. CHO cells in recombinant antibody production: What’s the …
Mar 3, 2022A review by Dumont et al. found that only five FDA-approved biotherapeutics are produced within HEK, and 50 with CHO (as of 2016). CHO cells are robust hosts that grow well in suspension culture, can easily be adapted to serum free media, and can produce and secrete recombinant antibodies in the multi-gram scale.(12)
The fickle CHO: a review of the causes, implications, and potential …
product quality. In this review, we provide a definition for titer and quality stability and discuss the main causes of the CHO … Chinese hamster ovary (CHO) cell lines have been preferentially used to pro-duce recombinant therapeutics and are used for manufacturing approximately 70% of all recombinant biopharmaceutical(13)
HEK Cells vs. CHO Cells in Recombinant Antibody Production: What’s the …
CHO cells are the workhorse of the biopharma industry — over 70% of biopharmaceuticals, and almost all antibodies, are produced within this cell line. A review by Dumont et al. found that only five FDA-approved biotherapeutics are produced within HEK, and 50 with CHO (as of 2016). CHO cells are robust hosts that grow well in suspension …(14)
Metabolic engineering of CHO cells for the development of a robust …
Chinese hamster ovary (CHO) cells are the most preferred mammalian host used for the bio-pharmaceutical production. A major challenge in metabolic engineering is to balance the flux of the tuned heterogonous metabolic pathway and achieve efficient metabolic response in a mammalian cellular system. Pyruvate carboxylase is an important network …(15)
CHO Media Development for Therapeutic Protein Production
Cell culture medium plays a crucial role in industrial biopharmaceutical processes since it provides essential nutrients and the proper environment for high viable cell density and efficient therapeutic protein expression. Besides growth and productivity, other media performance aspects should be considered, such as product quality and medium powder manufacturability. In the past few decades …(16)
Chinese Hamster Ovary (CHO) Cells Expression system
Origin of CHO cell line. Chinese hamsters had been used in research since 1919, originally for typing pneumococci. In 1957 it was used to derive the original Chinese hamster ovary cell line, named CHO-K1. Under laboratory conditions, scientists constantly try to improve CHO-based recombinant protein titer and quality achieving the biggest …(17)
PDF Literature Review: CHO versus HEK Cell Glycosylation – MaxCyte
and CHO Cells. J. Biotech. 2012, 161: 336-348. The authors of this paper concluded that proteins expressed in CHO and HEK cells had significant differences in glycostructures, including a consistently increased number acidic isoforms in CHO cells due to a higher level of sialylation. Glycoanalysis of 12 different proteins transiently(18)
PDF Recombinant Protein Therapeutics from CHO Cells – 20 Years and … – AIChE
effects of senescence. However, CHO cells have been proven safe, with the value of products being generated considerably outweighing any associated risks. Downstream processes for CHO cell products have matured to a stage where they can be purified to contain not more than picogram levels of contaminating CHO DNA per dose of the product (26 …(19)
Impacts on Product Quality Attributes of Monoclonal Antibodies Produced …
CHO cells were ~2 x 106 cells/mL, or late in culture, during perfusion of 2 L/day when CHO cells were 9-12 x 106 cells/mL and compared to control uncontaminated bioreactors.(20)
Excerpt Links
(1). Glycoengineering of CHO Cells to Improve Product Quality
(2). A Review on the Current Methods of Chinese Hamster Ovary (CHO) Cells …
(3). Glycoengineering of CHO Cells to Improve Product Quality
(4). CHO Cells – The Top Expression System of Best Selling Biologic Drugs
(5). CHO Cell Engineering for Improved Process Performance and Product Quality
(6). PDF Product Quality Review(s) – Food and Drug Administration
(7). CHO Cell Engineering for Improved Process Performance and Product Quality
(8). Recent advances in CHO cell line development for … – ScienceDirect
(9). Advances in recombinant antibody manufacturing – PMC
(10). CHO Cell Line Investigation for CMC Readiness – BioProcess …
(11). CHO Cell Line: From Reliable Workhorse to State-of-the-art Protein …
(12). HEK cells vs. CHO cells in recombinant antibody production: What’s the …
(13). The fickle CHO: a review of the causes, implications, and potential …
(14). HEK Cells vs. CHO Cells in Recombinant Antibody Production: What’s the …
(15). Metabolic engineering of CHO cells for the development of a robust …
(16). CHO Media Development for Therapeutic Protein Production
(17). Chinese Hamster Ovary (CHO) Cells Expression system
(18). PDF Literature Review: CHO versus HEK Cell Glycosylation – MaxCyte
(19). PDF Recombinant Protein Therapeutics from CHO Cells – 20 Years and … – AIChE
(20). Impacts on Product Quality Attributes of Monoclonal Antibodies Produced …
